These antioxidants also help to protect the structural integrity of ischaemic or hypoxic tissues, and might have useful anti-thrombotic actions as well. Prevention, treatment, or palliation of cancer, cardiovascular disease, infection, inflammatory disorders, and some
complications arising out of diabetes could probably be better managed by supplementating with high doses of nutritional antioxidants.15 RAD001 mw Antioxidants play a vital role in both food systems as well as in the human body to reduce oxidative processes. In food systems, retarding lipid peroxidation and formation of secondary lipid peroxidation product can be prevented by the use of nutritional antioxidants thereby helping to maintain flavour, texture, and the colour of the food product during storage. Also learn more antioxidants are helpful in reducing protein oxidation as well as the interaction of lipid-derived carbonyls with proteins that leads to an alteration of protein function.26 Natural antioxidants such as vitamin C, tocopherols along with herbal extracts like rosemary, sage and tea have already been commercialized to be used as alternatives to synthetic antioxidants in food systems.27 Proteins and protein hydrolysates derived from sources like milk, soya, egg, and fish also exhibit antioxidant activity in various muscle foods.28, 29 and 30 In the human body, oxidative damage caused by reactive oxygen and
reactive nitrogen species such as hydroxyl radicals (OH−), peroxyl radicals (OOR−), superoxide anion (O2−), and peroxynitrite (ONOO−) is protected ADAMTS5 with the help of endogenous antioxidants. The endogenous antioxidative systems include enzymes such as superoxide dismutase, catalase, and glutathione peroxidase, along with various non-enzymatic compounds such as selenium, α-tocopherol, and vitamin C.31 Apart from these, contribution of amino
acids, peptides, and proteins also helps in overall antioxidative capacity of cells and towards maintaining the health of biological tissues. For example, blood proteins are estimated to scavenge 10–50% of the peroxyl radicals formed in the plasma.32 and 33 Peptides like carnosine, anserine, and glutathione are well-known for their endogenous antioxidative activity.34 However, with progression of age the antioxidant-prooxidant balance in human body changes along with other factors such as environmental pollutants, fatigue, excessive alcohol intake, and high fat diets. The plasma and cellular antioxidant potential as well as the absorption of nutrients, including antioxidants, gradually diminish with progressing age.35 and 36 Researches have also indicated an accumulation of protein carbonyls with the ageing process in humans as a result of the action of free radicals on the proteins.37 and 38 Use of dietary antioxidants has been recognized as potentially effective to promote human health by increasing the body’s antioxidant load.