Repeat testing for anti-HBc, HBsAg, anti-HBe, and anti-HBs may help rule out a false-positive result, and vaccination might be in order.[8, 9] The presence of IgM anti-HBc or anti-HBe would Sirolimus molecular weight indicate recent HBV infection or prior exposure to HBV, respectively, and further follow-up to assess serum alanine aminotransferase activity and changes of serological markers may be necessary. Finally, in individuals with persistent isolated anti-HBc, serum HBV DNA to exclude chronic HBV infection and screening for HCV and HIV may also merit consideration.[8, 9] “
“The aim of the study was to assess whether pill burden is associated with self-reported adherence to current
combination antiretroviral regimens and health status in a large sample of unselected and chronically treated HIV-infected patients. An adherence and health status questionnaire was offered to all patients collecting their drugs between March and May 2010 at our clinic; both parameters were primarily evaluated using a visual analogue scale. Linear correlations were evaluated using Spearman’s correlation coefficient. Wilcoxon’s rank-sum test and the χ2 test were used to compare quantitative and qualitative PTC124 cell line variables. The generalized linear model was used in multivariable analyses.
Among 2763 subjects on treatment during the study period, 2114 (78.8% male; mean age 46.9 ± 8.84 years) were tested for adherence; 1803 (85.3%) had viral loads < 50 HIV-1 RNA copies/mL. After adjusting for age, gender, HIV risk factor, current CD4 count, pill burden and dosing interval, adherence was higher in patients with undetectable
HIV RNA (P < 0.0001) and directly associated with current CD4 count (P = 0.029). After adjusting for the same variables, health status was better in patients with undetectable viraemia (P = 0.004) and in men who have sex with men (MSM) and heterosexuals compared with injecting drug users and those with other risk factors (P < 0.0001 for MSM and P = 0.008 for heterosexuals); it was also directly associated with current CD4 count (P < 0.0001) and inversely associated with age (P < 0.0001) and pill burden (P = 0.019). In this highly adherent population, the number of daily pills was related to self-reported Phosphoglycerate kinase health status but not to self-reported adherence, whereas the dosing interval did not influence self-reported adherence or health status. “
“Linkage to care after HIV diagnosis remains underinvestigated in Europe, yet delays in linkage to care are an important obstacle to controlling the HIV epidemic. The Test and Keep in Care (TAK) project aims to determine the prevalence of HIV-positive persons who are lost or late to care and factors associated with this. Data from community-based voluntary counselling and testing that occurred in 2010–2011 were linked with data from HIV clinics using unique test numbers. Persons not registered in HIV clinics were considered lost to care (LTC).