Follow-up evaluations were Luminespib order performed www.selleckchem.com/EGFR(HER).html thereafter every 3 months for 3 years by endoscopy and CT scan. After 3 years, patients were seen every 6 months. During the follow-up period, a routine course of physical examinations and clinical laboratory tests was performed to check the patient’s health. Severe acute toxicities A definitive 5-FU/CDDP-based CRT is associated with acute toxicities, predominantly leucopenia, stomatitis, and cheilitis [5–9]. Toxicity was evaluated using criteria defined by the Japan Clinical Oncology Group . These criteria were based on the National Cancer Institute Common Toxicity Criteria. Toxicity was assessed on a 2 to 3 day basis during the CRT and subsequent hospitalization
period and on every visit after the completion of CRT. Episodes of leucopenia, stomatitis, and cheilitis during the first 2 courses GSK2126458 order and subsequent 2 weeks (until day 70) were recorded as acute toxicities and those of grade 3 or more as severe acute toxicities. Survival
after treatment with a 5-FU/CDDP-based CRT Survival time was defined as the time from treatment initiation to death from any cause or to the last date of confirmation of survival. Survival data were updated on June 25, 2011. Data analysis and statistics All values reported are the mean ± standard deviation (SD). The unpaired Student’s t-test/Welch’s test or Mann-Whitney’s U test was used for two-group comparisons, and AVOVA was for multiple comparisons. Fisher’s exact test was also used for the analysis of contingency tables. The difference of overall survival curves was analyzed by Log-rank test. P values of less than 0.05 (two tailed) were considered to be significant. Results Demographic/clinicopathologic characteristics and clinical outcome of 49 Japanese ESCC patients are summarized in Table
1. The 1-year, 2-year, and 5-year survival rates were 71.4%, 57.1%, and 42.9%, respectively. The patients who survived 5 years or more were older (P = 0.020) and heavier (P = 0.019) than Olopatadine those who lasted less than 5 years. There was a significant difference in disease stage between the 2 groups (P = 0.048). The CR rate was 76.2% for the patients surviving 5 years or more, but only 25.0% for the others (P = 0.0005). No differences were found in the frequency of episodes of severe acute leucopenia, stomatitis, and cheilitis. Table 1 Demographic/clinicopathologic characteristics and clinical outcome after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in 49 Japanese patients with esophageal squamous cell carcinoma Group Total Survival of 5 years or more Survival of less than 5 years P a) N 49 21 28 1) Demographic/clinicopathologic Age, yr 64.5 ± 7.4 (48 -78) b) 67.3 ± 5.8 (60 -78) 62.4 ± 7.9 (48 -76) 0.020 Height, cm 163.5 ± 6.6 (150-180) 161.9 ± 6.1 (150-171) 164.8 ± 6.8 (152-180) 0.125 Weight, kg 56.1 ± 9.6 (33-79) 59.8 ± 9.