We observed an increase of PSMA expression in prostate cancer. It’ is seems to indicate a more extensive role of PSMA in prostate cancer. Low expression in normal tissue would suggest a limited role of PSMA in normal human prostate and low expression in benign prostate hyperplasia tissue may suggest a limited role of this protein in hyperplastic tissue [17, 34]. Our finding is consistent with previous reports Combretastatin A4 purchase using immunohistochemistry and multiplex PCR reactions to demonstrate the association between PSMA and tumor progression [17, 34, 35]. A notable finding in our study revealed that in NP the expression of PSMA and PSA seems

to be identical. However, PSMA expression in hyperplastic and neoplastic prostates tissues appears to be inversed to the PSA expression. Although PSMA is more expressed in malignant prostate than benign prostatic hyperplasia, PSA is highly expressed in hyperplastic tissues. This is in part, thought to be due to the differences observed in several biological features between peripheral and transition zone of the prostate gland [2]. Although, the majority of the glandular tissue in prostate is located in the peripheral zone, the PSA tissue is secreted at higher levels by benign prostate epithelium arising exclusively in the transition zone compared JNJ-26481585 cost to

prostate cancer developing mainly in peripheral zone [36, 22]. The majority of our samples diagnosed with prostate cancer have a Gleason grade ≥7. However, regarding to PSA expression we observed a bi-modal distribution of expression of this marker in carcinomatous prostate samples. This is seems to be related to two mechanisms of growth of this prostate cancer tissue (data not shown). The study of distinct pattern of prostate tumor profiles MRT67307 order produced by prostate epithelial cells depending on positive immunoreactions to PSA and PSMA showed a high immunoexpression of the profile (PSA+, PSMA+) in all histological prostate tissues. In this

latter profile, PSA and ADP ribosylation factor PSMA are more expressed in BPH compared to NP. The PSMA was highest in neoplastic cells, whereas PSA was highest in benign cells in the same profile. For the profile (PSA+, PSMA-) expression levels decreases between normal prostate, benign prostatic tissue and primary prostate cancer. Inversely, the profile (PSA-, PSMA+) expression increases from NP, BPH to PC patients. Compared to BPH patients, the profile (PSA-, PSMA-) is absent in both normal and prostate cancer tissue. These data suggest that these markers are regulated differentially in their expression and this difference seems to increase with malignant transformation [34]. The preponderance of PSMA or PSA expression in each prostatic subgroup depends on the cellular context.