This study provides an evaluation of the systemic response characteristics of female baboons to ligature-induced periodontitis during pregnancy. Our findings support that ligature-induced periodontitis in baboons elicits changes in systemic inflammatory mediators. Moreover, a subset of the population of baboons that
demonstrated a greater clinical response to Talazoparib mouse ligation during pregnancy exhibited a discrete systemic inflammatory response. This model of periodontitis and pregnancy resulted in alterations in the level of serum inflammatory mediators throughout the pregnancy and will provide an opportunity to delineate risk factors for oral–systemic disease linkages. This work was supported by USPHS grant DE13958 from the National Institute of Dental and Craniofacial Research. We would like to thank Scott Eddy, Robert Ayala and Malini Bharadwaj for technical support in developing and managing these data. We acknowledge the crucial contribution of Drs Kathleen Brasky, Karen Rice and the scientific and technical staff at the Southwest Foundation for Biomedical Research and contribution from USPHS grant 13986 in support of the Southwest National Primate Research Center at the Foundation. The authors
claim no conflict or financial interests related to the research reported. “
“Effective humoral Tamoxifen immunity depends on B cells, plasma cells and follicular helper T cells (TFH) and secreted high-affinity antibodies. The differentiation of mature B cell into plasma cells is ultimately hardwired in a regulatory network of transcription factors. This circuitry is responding to extracellular stimuli, which leads to production of higher-affinity antibodies after germinal centre (GC) reaction. The understanding of the transcriptional regulation of GCs and the
initiation of plasma cell differentiation is becoming increasingly clear. It is evident that transcriptional repressor Blimp-1 can drive the plasma cell differentiation, but the initiation of plasma cell differentiation in GCs is likely coupled to Axenfeld syndrome the loss of B cell characteristics maintained by transcription factors Pax5 and Bcl6. Upon activation with appropriate stimuli, most notably the antigen recognized by the B cell antigen receptor (BCR), the resting naive B cells start to proliferate. A subset of these cells starts to secrete antibody and are referred to as plasmablasts. These cells may undergo terminal differentiation in tissues, where they continue antibody secretion and stop the proliferation, and are defined as plasma cells. Plasma cells represent the final differentiation stage of the B cell lineage and are the professional antibody-secreting cells constituting a major branch of humoral immunity.