The hair of cattle races such as Holstein-Friesian and Red Pied showed lower Bos d 2 contents compared to other races. Results of the epidemiological cattle allergy study CAS showed cattle related sensitization in cattle farmers of northern Germany toward cattle races such as Holstein-Friesian in almost the same https://www.selleckchem.com/products/Cyclosporin-A(Cyclosporine-A).html manner as in regions of southern Germany, which were dominated by cattle races such as German Brown and Simmental with a higher Bos d 2 content (Heutelbeck et al. 2007). Further investigations shall investigate whether other cattle allergens besides Bos d 2 represent the airborne availability AZD1480 of allergological
significant cattle allergens more appropriately. Beside environmental influences other factors such as genetic traits, e.g., an atopic predisposition, are relevant for occupational sensitization. We therefore recommend the consideration of not only the occupational environment but learn more also the individual factors of the subjects in the prevention of occupational allergy. In conclusion several practical consequences can be derived from our experiments: If the results with commercial cow allergen extracts are inconsistent, extracts of own cattle hair should be used in diagnostic immunoblot investigations. A
possible lack of relevant proteins in commercial extract may be an explanation for inconsistent results of clinical symptoms and in vivo or in vitro diagnostic methods. In the light of our results, an international standard for cattle hair/dander extracts needs to be discussed, especially with regard to the estimation of the antigen content. Acknowledgments We are grateful for the support we received in the course of our study. In particular, we would like to thank the enough Agricultural Institutions for Statutory Accident Insurance and Prevention in Germany and Petra Tucholla, Anke Seeckts and Robert Metzner for technical assistance
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