pylori infection (detected by stool antigen) and venous blood ammonia concentration. Exclusion criteria: clinical hepatic encephalopathy, illiteracy, ongoing alcohol consumption, ongoing or recent gastrointestinal bleeding or spontaneous bacterial peritonitis, proton pump inhibitors or psychotropic drugs use and recent H. pylori therapy. Statistical learn more significance was established at p < 0.05. Results: RESULTS: From the 102 patients who were evaluated, 41 were included: 31 men, mean age of 57 years, 81% with alcoholic cirrhosis, 31 in class A and 10 in class B (Child-Pugh), mean MELD of 6. SHE was diagnosed in 34% of patients. The prevalence of H. pylori infection was

22%. Hyperammonemia was found in 98% of patients. Levels of blood ammonia were not significantly different between patients with or without H. pylori infection (49.8 ± 18.8 vs 45.7 ± 13.6 μmol/L; p = 0.468) nor between patients with or without AZD1152-HQPA cost SHE (48.50 ± 13.3 vs 45.6 ± 15.6 μmol/L; p = 0.555). The rate of SHE was higher in patients with H. pylori infection (56% vs 28%), although without statistical significance. There was a significant positive correlation between ammonia levels and MELD (p = 0.009). Conclusion: About one-third of cirrhotic patients have SHE. H. pylori infection was not associated with the presence of SHE. Patients

with more severe liver disease have higher levels of ammonia, which are not related with H. pylori infection. Key Word(s): 1. encephalopathy; 2. H. pylori; 3. hyperammonemia; Presenting Author: ATSUSHI MITSUNAGA Additional Authors: TOMOKO TAGATA, TETSUYA HAMANO, HONAMI TERAMOTO, YUTAKA MITSUNAGA, IZUMI SHIRATO, MIHO SHIRATO, MASAHIKO SHIMADA, TAKAYOSHI NISHINO Corresponding Author: ATSUSHI MITSUNAGA

Affiliations: Tokyo Women’s Medical University Yachiyo Medical Center Objective: The fact that stomach cancer under occurs the circumstances of chronic inflammation from Helicobacter Pylori (HP)infection is common knowledge. It is also becoming clear that stomach cancer occurrence is suppressed by eradication of HP. However, there is a limit to the results of suppressing stomach cancer by HP eradication, and it is a fact that even after HP eradication stomach cancer occurs at a fixed rate. As far as we could search in Ichushi (Japan Medical Abstracts Society), in cases of early gastric cancer treated Phosphoglycerate kinase with endoscopy, in metachronous cancer which occurred after successfully eradication via HP eradication treatment, 11.2 years after HP eradication was the longest observed period. On this occasion, in spite of HP eradication being carried out after treatment of early gastric cancer with endoscopy, we experienced a case of metachronous repeated cancer occurrences over a period of 13 years following and we therefore make this report. Methods: Case: 56 year old male. In March of 1998, Endoscopic Mucosal Resection (EMR)was performed on IIa type early gastric cancer (12 mm) in the posterior wall of the antrum.