78; 95%CI 0 96 to 2 53, p 0 38) However the overall effect leans

78; 95%CI 0.96 to 2.53, p 0.38). However the overall effect leans toward the study treatment (prucalopride). The test for heterogeneity was not significant. The numbers of adverse events were more common with prucalopride than with placebo (RR 1.22; 95% CI 1.14 to 1.32, p < 0.00001). Conclusion: Prucalopride has no significant effect compared to placebo for the treatment of chronic idiopathic constipation. The drug appeared safe, but adverse events were significantly common, particularly headache, nausea and diarrhea, and patients should be warned of these potential side effects of treatment. Key Word(s): 1. Prucalopride;

2. Chronic constipation; 3. Efficacy; 4. Side effects; Presenting Author: HUI SU Additional Authors: JUNGUO JIANG, LIANGKUI LIU, MINGMING MENG, HONG LIU, JING

Metabolism inhibitor WU Corresponding Author: JING WU Affiliations: Objective: take high resolution gastrointestinal examination and 24 hour esophageal PH -Z monitoring, for systemic sclerosis patients with symptoms of gastrointestinal involvement, to improve the understanding of the gastrointestinal involvement manifestations in systemic sclerosis patient. Methods: for 1 case of gastrointestinal involvement of systemic sclerosis patient, INK 128 ic50 take high resolution esophageal pressure monitoring, 24 hours esophageal PH -Z monitoring, high resolution anorectal pressure monitoring (3D), to analyze the result, explain the clinical symptoms. Results: esophageal pressure monitoring showed esophageal body no creep, LES pressure relief; 24 hours

PH-Z monitoring showed severe gastroesophageal reflux, visible obvious weak acid reflux, correlation analysis considering the symptoms associated with acid reflux; Anorectal pressure monitoring showed the anal sphincter pressure band short, anal sphincter resting pressure and maximum systolic pressure is normal, the anorectal inhibitory reflex, simulated defecate are normal, defecate initial feeling and maximum tolerance amount are significantly 4-Aminobutyrate aminotransferase reduced. Conclusion: high resolution gastrointestinal monitoring can make us intuitive see the manifestations of esophageal sphincter and esophageal peristalsis, rectum anus defecate function affected in systemic sclerosis patients with gastrointestinal involvement. Key Word(s): 1. systemic sclerosis; 2. Gastrointestinal; 3. dynamics; 4. High resolution; Presenting Author: HOYEEW HIRAI Additional Authors: SIEWC NG, JESSICAYL CHING, JAMESYW LAU, RAYMOND TANG, ARICJ HUI, PHYLIS LAM, ALMAN CHUI, ALICE FAN, JUSTIN WU, FRANCISKL CHAN, JOSEPHJY SUNG Corresponding Author: HOYEEW HIRAI Affiliations: The Chinese University of Hong Kong Objective: Few studies have evaluated risk factors and the magnitude of risk for advanced colorectal neoplasms and serrated lesions in Chinese subjects.

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