(The Journal of Neuropsychiatry and Clinical Neurosciences 2010; 22:395-400)”
“There is limited data about the mucosal lesions of portal hypertensive enteropathy (PHE) detected
NU7026 mouse by capsule endoscopy, and there is no scoring system to evaluate their severity. Our aim is to create a reliable scoring system for PHE, and to explore the possible usefulness of using transient elastograhy (TE) in that field. We compared the medical records of 31 patients with liver cirrhosis and portal hypertension with 29 control patients. We found that the mucosal lesions compatible with PI-LE were significantly more common in cirrhotic patients than in control patients (67.7% vs 6.9%, p<0.001). Cirrhotic patients with high TE score (p = 0.018), high Child-Pugh grade, large esophageal β-Nicotinamide in vivo varices (EV), portal hypertensive gastropathy, and history of endoscopic variceal injection sclerotherapy or ligation
(EIS/EVL) were significantly associated with PHE. Using our scoring system, we found that patients with higher TE score (p = 0.004), high Child-Pugh score (p = 0.011), larger EV (p = 0.006), and prior EIS/EVL (p = 0.006) were significantly associated with higher PILE score. We concluded that using our scoring system might be helpful in grading PHE severity, and TE might
be a new non-invasive method for detecting the presence and severity of PHE in cirrhotic patients.”
“Human reproduction is a complex process involving multiple factors for the success of pregnancy. Chemokines are click here one of the immunomodulators which may determine pregnancy outcome. In the present study, we have tested genetic association between CCR5 Delta 32 polymorphism and idiopathic recurrent miscarriages (IRM) among north Indians.
Two hundred patients and 300 age, sex and ethnically matched controls were genotyped for CCR5 Delta 32 polymorphism, genotype and allele frequencies were compared in both the groups.
IRM patients had a three times higher (5.5 vs. 1.7%) frequency of heterozygote genotype (P = 0.0335, OR = 3.43; 95% CI = 1.17-10.04). Allele frequency in IRM patients was 3.7 and 0.83% among controls and the differences were statistically significant (P = 0.0349, OR = 3.37; 95% CI = 1.16-9.76).
Our results demonstrated that it had a higher frequency of CCR5 Delta 32 at allelic level suggesting a possible susceptibility trend (OR = 3.43) and CCR5 Delta 32 may be a potential genetic risk factor for IRM.