PubMedCrossRef 56. Clinchy B, Bjorck P, Paulie S, Moller G: Interleukin-10 inhibits motility in murine and human B lymphocytes. Immunology 1994, 82:376–382.PubMed 57. Parekh VV, Prasad DV, Banerjee PP, Joshi BN, Kumar A, Mishra GC: B cells activated by lipopolysaccharide, GSK2245840 cost but not by anti-Ig and anti-CD40 antibody, induce anergy in CD8+ T cells: role of TGF-beta 1. J Immunol 2003, 170:5897–5911.PubMed 58. Patil S, Wildey GM, Brown TL, Choy L, Derynck R, Howe PH: Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis. J Biol Chem 2000, 275:38363–38370.PubMedCrossRef Competing interests

The authors declare that they have no competing interests. Authors’ contributions ASV and AD made substantial contributions to conception and design as well as to the interpretation of the data and drafted the manuscript. TML and ASV carried out the experiments. TML, AR and MK contributed to conception, the interpretation of the data and assisted to draft the manuscript. MBB conceived of the study, participated in its design and coordination and helped to

draft the manuscript. All authors read and approved the final manuscript.”
“Background Gastric cancer is one of the most common malignancy. In the economically developping countries, gastric cancer is the second most frequntly diagnosed cancers and the third leading cause Selleck Rabusertib of cancer death in males Cetuximab [1], the overall 5-year survival rate is low (15% to 35%) because of the high recurrence rates, nodal metastasis and the short-lived response to chemotherapy [2]. In the present, more and more studies focus on the molecular diagnosis and therapy of gastric cancer [3]. Aryl ML323 price hydrocarbon receptor (AhR) is a ligand-activated transcription factor. After ligands such as polycyclic aromatic hydrocarbons (PAH) and halogenated hydrocarbons (HAH) bind with AhR in cytoplasm, the ligand-AhR complex is translocated to the nucleus and heterodimerizes

with the AhR nuclear translocator (ARNT). The complex binds to the cognate enhancer sequence and subsequently activates downstream gene expression [4]. Traditional studies of AhR function focused on its role in regulating the expression of xenobiotic metabolizing enzymes (XMEs) and mediating the xenobiotics metabolism. Recent studies demonstrated that AhR may involve in many important physiological and pathological processes including individual development, cell differentiation, and carcinogenesis [5]. AhR expression is upregulated in lung [6], mammary gland [7], pancreatic [8] and gastric cancers [9]. Further studies found that AhR played improtant roles in regulating cellular proliferation, apoptosis, cell cycle, migration and invasion [10]. As a protein related to cancer, AhR maybe a promising target for cancer therapy. Our previous work found that an AhR agonist, 2,3,7,8 –tetrachlorodibenzo -para-dioxin (TCDD), inhibited gastric cancer cell growth [9].