p.) within 1
min after pretreatment with microinfusions of M100907 (0.1, 0.3, 1.0, or 1.5 mu g/0.2 mu l/side) into the vmPFC.
Intra-vmPFC M100907 decreased cue-elicited reinstatement at the two highest doses (1.0 and 1.5 mu g) but produced only a slight decrease in cocaine-primed reinstatement that was not dose dependent. The decrease in cue reinstatement was not likely due to impaired ability to respond since intra-vmPFC M100907 infusions had minimal effect on cocaine self-administration and no effect on cue-elicited sucrose-seeking behavior, or CRT0066101 molecular weight spontaneous or cocaine-induced locomotion. M100907 infusions into the adjacent anterior cingulate cortex had no effect on cue reinstatement.
The results suggest that the blockade of 5-HT2A receptors in the vmPFC selectively attenuates the incentive motivational effects of cocaine-paired cues.”
“The effects of temperature acclimation and acute temperature change were investigated in postprandial green shore crabs, Carcinus maenas. Oxygen uptake, gut contractions and transit rates and digestive efficiencies
were measured for crabs acclimated to either 10 degrees C or 20 degrees C and subsequently exposed to treatment temperatures of 5, 15, or 25 degrees C. Temperature acclimation resulted in a partial metabolic compensation in unfed crabs, with higher oxygen uptake rates measured for the 10 degrees C acclimated group exposed to acute test temperatures. The Q(10) values were higher than normal, probably because the acute temperature change prevented crabs from fully Alectinib adjusting to the new temperature. Both the acclimation and GW4869 treatment temperature altered the characteristics of the specific dynamic action (SDA). The duration of the response was longer for 20 degrees C acclimated crabs and was inversely related to the treatment temperature. The scope (peak oxygen consumption) was also higher for 20 degrees C acclimated crabs with a trend towards an inverse relationship with treatment temperature. Since the overall SDA (energy
expenditure) is a function of both duration and scope, it was also higher for 20 degrees C acclimated crabs, with the highest value measured at the treatment temperature of 15 degrees C. The decline in total SDA after acute exposure to 5 and 25 degrees C suggests that both cold stress and limitations to oxygen supply at the temperature extremes could be affecting the SDA response. The contractions of the pyloric sac of the foregut region function to propel digesta through the gut, and contraction rates increased with increasing treatment temperature. This translated into faster transit rates with increasing treatment temperatures. Although pyloric sac contractions were higher for 20 degrees C acclimated crabs, temperature acclimation had no effect on transit rates. This suggests that a threshold level in pyloric sac contraction rates needs to be reached before it manifests itself on transit rates.