Nevertheless, considering the inherent spatial
resolution limit for PET of 700μ, the superior microscopic resolution of MRI of 4 μ presents a strong incentive for research into ligand-based molecular MRI. 17O exhibits JJ vicinal coupling with a covalently bound proton in a hydroxyl group. This 17O coupled proton can be ionized in water solution and interexchange with other water protons. This property can be utilized as “probe” in T2-weighted imaging and developed into ligand-based molecular MRI. We examined β-amyloid distribution in human APP overexpressed transgenic mice in vivo following injection of 17O labeled Pittsburg compound B (17O-PiB). JJVCPE imaging successfully imaged 17O-PiB, unequivocally establishing that 17O JJVCPE imaging can be developed into PET-like molecular MRI in clinical medicine. find more The study represents the first successful ligand-based molecular MRI in vivo. This is also the first in vivo amyloid imaging using MRI. High-resolution molecular MRI with high specificity under clinical settings, such as in vivo microscopic imaging of senile plaque, is a foreseeable aim. “
“Vasospasm has been considered the most severe acute complication after subarachnoid
hemorrhage (SAH). MRA is not considered ideal for detecting cerebral vasospasm because of background including Ku-0059436 order the hemorrhage. The aim of this study is to evaluate the efficacy of Subtraction MRA (SMRA) by comparing it to that of conventional MRA (CMRA) for diagnosis of cerebral vasospasm. Arteries were assigned to one of three categories based on the degree of MRA diagnostic quality of vasospasm (quality score): 0, bad … 2, good. Furthermore each artery was assigned to one of four categories based on Flavopiridol (Alvocidib) the degree of vasospasm severity (SV score): 0, no vasospasm … 3, severe. The value of the difference between DSA-SV score and MRA-SV score was defined as the DIF score. CMRA and SMRA were compared for each arterial region with regard to quality score and DIF score. The average CMRA and SMRA quality score were 1.46 and 1.79; the difference was statistically significant. The
average CMRA and SMRA DIF score were 1.08 and .60; the difference was statistically significant. Diagnosis of cerebral vasospasm is more accurate by SMRA than by CMRA. The advantages are its noninvasive nature and its ability to detect cerebral vasospasm. “
“Infarct volume ≥100 mL on diffusion weighted imaging (DWI) predicts symptomatic hemorrhagic transformation and poor outcome. Our aim was to determine the correlation between the Alberta Stroke Program Early CT Score (ASPECTS) and infarct volume and to identify the optimal value for describing infarcts ≥100 mL. This was a retrospective study of acute infarcts isolated to the middle cerebral artery territory imaged by DWI <48 hours from ictus. Two neuroradiologists blinded to volumetric measurements assigned ASPECTS while a third observer used a semi-automated thresholding technique to determine infarct volume.