Moreiras Tuni O, Carbajal Azcona Á, Cabrera L: Tablas de composición de alimentos. Madrid: Ediciones Pirámide; 2005. Competing LOXO-101 molecular weight interests The authors declare that they have no competing interests. Authors’ contributions All authors read and extensively reviewed and contributed to the final manuscript as follows
MAJ: Conception and design, analysis and interpretation of the data, drafting and critically reviewing the manuscript. SCP: Interpretation of the data, drafting and critically reviewing the manuscript. UA: Drafting and critically reviewing the manuscript. MSJ: Drafting and critically reviewing the manuscript. SJ: Conception, interpretation of the data, drafting and critically reviewing the manuscript. All authors read and approved the final version of
https://www.selleckchem.com/products/MLN-2238.html the manuscript.”
“Introduction Among solid gynaecological tumors, breast cancer is the most often diagnosed tumour while ovarian cancer is the most deadly gynaecological neoplasia. Cisplatin plays a completely different but important role in the treatment of both female cancer types. In ovarian cancer treatment, Platinum-based chemotherapy plays a pivotal role as first line chemotherapy option and is usually combined with taxanes . In breast cancer treatment, cisplatin yet only is regarded a cytostatic reserve. According to current guidelines, treatment of breast cancer normally is performed as chemotherapy triplets. The most commonly used cytostatics in the clinical management of the disease are Anthracyclines, Cyclophosphamide, Fluorouracil, and Taxanes, respectively. Prominent examples of chemotherapy combinations selleck chemicals llc in breast cancer treatment are: ➢ FEC: Fluorouracil, Epirubicin, Cyclophosphamide ➢ FAC: Fluorouracil, Doxorubicine (Adriamycine), Cyclophosphamide ➢ TAC: Docetaxane, Doxorubicine, Cyclophosphamide ➢ EC – P (or EC – D): Epirubicine, Cyclophosphamide followed by either Paclitaxane or Docetaxane ➢ FEC-Doc: Fluorouracil, Epirubicine, Cyclophosphamide Lepirudin followed by Docetaxane ➢ TC: Docetaxane,
Cyclophosphamide ➢ Formerly often applied CMF treatment regime (consisting of Cyclophosphamide, Methotrexate, and Fluorouracil) is nowadays more or less completely substituted by the above mentioned. Thus, cisplatin at present does not play a pivotal role in clinical breast cancer therapy. However, Platinum-based chemotherapy could develop into a highly important new treatment modality with respect to yet incurable triple negative breast cancer (TNBC) . Especially two TNBC subgroups seem to be amenable to Platinum-based chemotherapy: basal-like 1 and 2 (BL1, BL2). These two subgroups are identified by their Gene Expression Signature (GES) . BL1 and BL2 subgroups of TNBC are characterized by high expression levels of DNA-damage response genes, which induce cell cycle arrest and apoptosis . Interestingly, in vitro cell culture experiments unveiled this phenomenon and can possibly serve to predict the in vivo situation .