Follow-up at regular intervals included clinical evaluation, Harvey-Bradshaw index, laboratory tests, colonoscopy and small, bowel radiology when appropriate.
Results: The perioperative mortality was nit. Early postoperative complications were: wound infection (N=4), anastomotic teak (N=1), reoperated, nipple ischemia (N=1) reoperated, enterocutaneous fistula GSK3326595 (N=1). Clinical recurrence in the neoterminal ileum was after 1, 3, 4 and 5 years: 11%, 20%, 23% and 24%. Eleven patients (19%) were reoperated for recurrence in the neoterminal ileum
after median 96 months follow-up. The cumulative reoperation rate was after 1, 3, 4 and 5 years: 4%, 13%, 13% and 16%, respectively.
Conclusion: The low clinical and surgical recurrence rate in the neoterminal ileum may suggest a protective effect of the neosphincter on postoperative recurrence of Crohn’s disease. This result should be tested in a randomized controlled trial. (c) 2009 European Crohn’s and Colitis Organisation. Published by Elsevier B.V. All rights reserved.”
“A-to-I RNA editing is a post-transcriptional modification that converts adenosines to inosines in both coding and noncoding RNA transcripts. It is catalyzed by ADAR (adenosine GS-1101 ic50 deaminase acting on RNA) enzymes, which exist throughout the body but are most prevalent in the central nervous system. Inosines exhibit properties that are most similar to those
of guanosines. As a result, ADAR-mediated editing can post-transcriptionally alter codons, introduce or remove splice sites, or affect the base pairing of the RNA molecule with itself
or with other RNAs. A-to-I editing is a mechanism that regulates and diversifies the transcriptome, but the full biological significance of ADARs is not understood. ADARs are highly conserved find more across vertebrates and are essential for normal development in mammals. Aberrant ADAR activity has been associated with a wide range of human diseases, including cancer, neurological disorders, metabolic diseases, viral infections and autoimmune disorders. ADARs have been shown to contribute to disease pathologies by editing of glutamate receptors, editing of serotonin receptors, mutations in ADAR genes, and by other mechanisms, including recently identified regulatory roles in microRNA processing. Advances in research into many of these diseases may depend on an improved understanding of the biological functions of ADARs. Here, we review recent studies investigating connections between ADAR-mediated RNA editing and human diseases.”
“OBJECTIVE: To determine whether avoiding intra-abdominal irrigation at cesarean delivery will decrease rates of intraoperative and postoperative gastrointestinal disturbance without increasing postoperative morbidity.
METHODS: This was a randomized controlled trial of patients undergoing cesarean delivery. Patients were randomized to irrigation after closure of the hysterotomy compared with no irrigation.