EPN is common in persons
with diabetes or urinary tract obstruction. Herein we report a case of bilateral emphysematous pyelonephritis in a postpartum lady who had no evidence of diabetes or urinary tract obstruction. Management of this condition has traditionally been aggressive, and surgery has been considered mandatory. Our patient LDC000067 was managed successfully with antibiotics and supportive measures alone.”
“BACKGROUND: A significant decrease in mean cardiomyocyte DNA content and increased numbers of diploid cardiomyocytes after unloading has been demonstrated, suggesting a numerical increase of cardiomyocytes. Despite a thorough search in that study, no mitoses explaining a potential net increase of cardiomyocytes has been observed. The heart harbors several stem cell populations, including c-kit (CD117)(+) stem cells and side population cells (SPC), which may proliferate after unloading and thus contribute to the generation of diploid cardiomyocytes. In this study we sought to determine, whether there is an increase of ABCG2(+) SPC and CD! 17 stem cells after unloading.
METHODS: In paired myocardial
samples (prior to and after LVAD), the number 10058-F4 nmr of cells with immunoexpression of ABCG2, c-kit/CD117 and MEF-2 was assessed by immunohistochemistry. Their number was morphometrically determined and these data were correlated with the mean cardiomyocyte DNA content.
RESULTS: A significant increase of SPC and cells with coexpression of c-kit and AZD2014 molecular weight MEF-2 after unloading was observed from 0.00013% in CHF to 0.0011%, and 0.013% 10 0.035%, respectively after unloading (p = 0.001). A significant positive correlation between both SPC and cells with coexpression
of c-kit and MEF-2 expression was observed (p = 0.007 and 0.01). No correlation was found between the number of SPC and the mean cardiomyocyte DNA content.
CONCLUSIONS: SPC are increased significantly in the myocardium after ventricular unloading, suggesting a role for stem cell proliferation during “”reverse cardiac remodeling.”" These cells might proliferate and commit to different cell lineages, such as cardiomyocytes or endothelium, and thus ameliorate cardiac function. J Heart Lung Transplant 2012;31:318-24 (C) 2012 International Society for Heart and Lung Transplantation. All rights reserved.”
“The lack of use of a common grading system in reporting morbidity impedes estimation of the true risk to a right lobe living donor (RLLD). We report outcomes in 91 consecutive RLLD’s using the validated 5-tier Clavien grading and a quality of life (QOL) questionnaire. The median follow-up was 79 months. The donors were predominantly female (66%), 22 (24%) received autologous blood transfusions. Fifty-three complications occurred in 43 donors (47% morbidity), 19 (37%) were >= Grade III, biliary fistula (14%) was the most common.