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Macrophage plays an important role in the destabilization of atherosclerotic lesions. Molecular imaging approaches that target and image macrophages may be potentially useful towards predicting plaque vulnerability during the natural history of the disease [1–5]. Macrophages are effective efferocytes with the ability to recognize the externalized phosphatidylserine (PS) on the plasma membrane surface of apoptotic cells via the scavenger receptors and remove them from circulation and the arterial wall [6–9]. Phosphatidylserine is a naturally occurring phospholipid (PL) and its use for targeting macrophages may improve the biocompatibility of the contrast agent and avoid the use of exogenous targeting agents such as antibodies Benzatropine and peptides. This approach of using phosphatidylserine for targeting macrophages has been reported previously for magnetic resonance imaging of macrophage contents in atheroma with gadolinium-containing liposomes  but PS-containing micelles have not been reported. Lipid-polyethylene glycol (PEG) micelles have traditionally been used to solubilize hydrophobic drugs and solubilize hydrophobic nanoparticles into discrete clusters that can include either single or multiple nanoparticles in their cores and thus can achieve size tunability for particular application .