6%) developed acute kidney injury requiring hemodialysis or renal replacement therapy within 30 days post transplantation. No patient developed end-stage renal failure at the mean follow up of 59 + 36 months. Conclusion: With proper patient
selection, favorable short and long-term outcomes can be achieved in patients who receive combined heart and liver transplantation. Post-transplant PI3K inhibitor acute kidney injury is not uncommon, however it is not associated with long-term sequelae. MELD = Model for End-Stage Liver Disease BMI = Body Mass Index ISHLT = International Society for Heart and Lung Transplantation Disclosures: Jerry Estep – Consulting: Thoratec The following people have nothing to disclose: Abimbola Aderinto, Maha R. Boktour, Mina Elnemr, Andrea M. Cordero-Reyes, Sherilyn Gordon Burroughs, Ashish Saharia, Barry Trachtenberg, Arvind Bhimaraj, Rafik M. Ghobrial, Howard P. Monsour “
“Acoustic radiation force impulse (ARFI) technology, involving the shear wave velocity (SWV) with virtual touch tissue quantification (VTTQ), are currently available for the assessment of liver fibrosis, while
there is no index derived from the combination of SWV and blood tests. The aim of this study was to develop a new index for assessment of liver fibrosis. The subjects were 176 consecutive patients with hepatitis C (training set [n = 120] and validation set [n = 56]) who underwent liver biopsy in our institution. In the training set, SWV, international normalized ratio (INR) and alanine aminotransferase (ALT) correlated independently and significantly with fibrosis. According to this, we developed the VIA index = −1.282 + 0.965 × SWV + 1.785 INR + 0.00185 MDV3100 nmr ALT. The areas under the receiver–operator curve (AUROC) of the VIA index were 0.838 for the diagnosis of significant fibrosis (≥F2), 0.904 for the severe fibrosis (≥F3) and 0.958 for the cirrhosis (F4) in the training set. While in the validation set, AUROC of the VIA index were 0.917 for F2 or higher, 0.906 for F3 or higher and 1.000 for F4, respectively. AUROC of the VIA index was improved compared to SWV alone, equivalent for VIA for the diagnosis of F2 or higher, and superior
to that of FIB-4 index and aspartate aminotransferase-to-platelet ratio index for the diagnosis of F3 or higher and selleck F4. The VIA index is potentially more useful for assessment of liver fibrosis than SWV alone, and easily and accurately measures liver fibrosis stage. “
“Liver receptor homolog-1 (LRH-1) is a nuclear receptor that controls a variety of metabolic pathways. In cultured cells, LRH-1 induces the expression of CYP7A1 and CYP8B1, key enzymes in bile salt synthesis. However, hepatic Cyp7a1 mRNA levels were not reduced upon hepatocyte-specific Lrh-1 deletion in mice. The reason for this apparent paradox has remained elusive. We describe a novel conditional whole-body Lrh-1 knockdown (LRH-1-KD) mouse model to evaluate the dependency of bile salt synthesis and composition on LRH-1.