5. mean decreases in Ishak Fibrosisscore was 1.3. Conclusion: Entecavir is an effective treatment option for patients with HBV-related compensated or decompensated http://www.selleckchem.com/products/LDE225(NVP-LDE225).html cirrhosis, resulting in sustained virological suppression, histological improvement, and improvement or stabilization of liver function. Key Word(s): 1.

Nucleoside analog; 2. Liver histology; 3. cirrhosis; 4. antiviral efficacy; Presenting Author: YING LIU Additional Authors: WEI LU Corresponding Author: WEI LU Affiliations: Tianjin Second People’s Hospital Objective: To observe the levels of serum I-FABP, MLT, GAS of the acute liver failure rats and to analysis the relationship between these indicators and gastrointestinal dysfunction of these rats, and providing theoretical and experimental basis for the early prediction of gastrointestinal dysfunction with acute liver failure. Methods: 85 female healthy clean rats were randomly divided into ALF model group (n = 50) and normal control group (n = 35), all the rats were respectively adaptive fed for three days. ALF model rat were injected with 350 mg/Kg TAA (paired 40 g/L with NS) by intraperitoneal, injected again after 24 h, and ALF model of rats

were completed. The normal control group were injected with the same amount saline by intraperitoneal at the same time. The rats’blood were taken at 24 h, 36 h, 48 h after completed injection, and detected 上海皓元 the liver function, including ALT, AST, TBIL, and detected the levels of I-FABP, selleck kinase inhibitor MLT, GAS by enzyme-linked immunosorbent assay. The right lobe liver, the gastric

antral and 2 cm proximal duodenum were collected at the same time. All the samples were fixed by the buffer solution of 40 g/L formaldehyde, paraffin-embedded, sliced, stained by HE, and observed the pathological changes of the liver, gastric and duodenum tissue under the light microscope. SPSS16.0 statistical software were used for statistically analyzing the experimental data. The measurement data were shown with the, the difference of indexes between different group were test with the single-factor analysis of variance, the correlation of two index were test with Pearson correlation analysis (two-sided test), P < 0.05 was significant difference. Results: The clinical characteristics of two groups of rats: The control group: rats were activating freely, responsive, eating freely, defecated and urinating normally, and all of them were living animals. The ALF model group: rats were eating reduced, even refused to eat, were listlessness, drowsiness, coma, and unresponsive, the activity of them were reducing, their abdominal were bulging, seen obvious gastrointestinal-type et al, such performance as hepatic encephalopathy and gastrointestinal dysfunction. The comparison of liver function between the ALF model group and control group.