Methods: Chinese subjects aged 50 years and above were recruited from gastroenterology clinics of four major public hospitals in Singapore from 2004–2010. Endoscopy surveillance was offered for a minimum of 5 years. Informed consent was obtained from all subjects and the study was approved by the institutional review boards. The main outcome measurement is the number of
subjects who develop high grade dysplasia or gastric adenocarcinoma. Results: 3033 subjects with mean age 59 ± 7 years were recruited. 51% were male, 16% had family history of gastric cancer and 30% had H. pylori infection history based on their medical records. The prevalence of chronic gastritis, current H. selleck products pylori infection, atrophic gastritis and intestinal metaplasia
at baseline were 81%, 20%, 19% and 44% respectively. The study is in progress, 1,300 have completed 5 years surveillance and the rest will complete by 2015.18 high grade dysplasia or early gastric cancers were detected so far after an average follow up period of 3 years. 12 of those cases were high grade dysplasia or intramucosal carcinoma and 6 were invasive cancers in stage 1A or 1B. The interval between the most recent endoscopy with no abnormal findings and the endoscopy where cancer was diagnosed is 4–25 months. Conclusion: Endoscopic surveillance is effective, and has already selleck chemicals llc detected high grade dysplasia or early gastric cancer in a high risk Singaporean Chinese population. Key Word(s): 1. gastric caner; 2. endoscopy screening; 3. risk stratification; 4. cohort study; Presenting
Author: IOAN CHIRILA Additional Authors: STK38 FLORINDUMITRU PETRARIU, VASILELIVIU DRUG Corresponding Author: IOAN CHIRILA Affiliations: University of Medicine and Pharmacy Grigore T. Popa Iasi, National Institute of Public Health, Iasi, Romania; University of Medicine and Pharmacy “Grigore T. Popa” – Iasi; University of Medicine and Pharmacy Grigore T Popa Iasi Objective: The aim of the study was to determine the presence of gastro-esophageal reflux symptoms and the prevalence of gastro-esophageal reflux disease (GERD) in general urban population and to evaluate the type of diet associated with this pathology. Methods: A randomized sample of subjects (n = 300) from a general urban population from Iasi city selected from the family doctors patient lists was invited for interview in the doctor’s office. Selected subjects were evaluated for recent symptoms using Gastrointestinal Symptom Rating Scale (GSRS), for the diagnosis of GERD using Montreal criteria and for their diet using a food frequency questionnaire. Results: In the last 7 days preceding the survey, were present relevant symptoms for gastro-esophageal reflux in 26.4% of investigated subjects and GERD was diagnosed in 31.1% of subjects. People aged over 50 years experienced an increased prevalence of recent symptoms (36.4%, p < 0.001) and GERD (37.