aeruginosa (0.0156 mg/ml), K. pneumonia (0.0156 mg/ml),

B. subtilis (0.0156 mg/ml) and activity against E. coli (0.0156 mg/ml) is comparable with the standard antibacterial agent Tetracycline. Compound 2g shows good activity among all the compounds against S. typhi (0.0625 mg/ml). In antifungal assay, all the compounds 2a–j displayed good antifungal activities against fungi A. flavus (0.0625–0.46 mg/ml), A. fumigatus (0.125–3.75 mg/ml). Compounds 4a–i demonstrated moderate results against the fungi A. niger (0.125–7.5 mg/ml). The evaluation of the antioxidant effects of the newly synthesized compounds having different concentrations were examined by well documented in vitro assay i.e. DPPH free radical scavenging assay. Antioxidant reacts with a stable free radical DPPH and converts it to 2,2-diphenyl-1-picryl hydrazine. The degree of Galunisertib solubility dmso decoloration indicates the scavenging potentials of the compound. The percentage (%) DPPH activities

of all the synthesized compounds have been shown in Table 2. The investigation of DPPH assay reveals that the, BMS 354825 compound 2g shows good activity comparable with the standard compound Ascorbic acid. Remaining compounds exhibited moderate to good activities as shown in Table 2. A series of novel formazans containing 3,4-dimethylpyrrole moiety were synthesized and their structures were confirmed by IR, 1H & 13C NMR, mass spectroscopy. The antimicrobial and antioxidant activities of the new compounds were evaluated. The results of preliminary bioassays of derivatisation of Schiff bases to formazan indicate that a number of these molecules exhibits moderate to good antibacterial, antifungal and antioxidant activities some of which are comparable to standard used in this study. The outcome indicates that there is a good scope for evaluation of this class of compounds as potential leads towards antimicrobial and antioxidant agents. All authors have none to declare. JDB is thankful to UGC-SAP for RFSMS Fellowship. “
“Natural products principally medicinal plants have long been prescribed in traditional medicine for centuries for treating different diseases. The significance

of herbs in the management of human ailments cannot be overemphasizing. The repetitive below investigation into the secondary plant metabolites for anti-infective agents has gained consequence because of the alarming increase in the rate of antibiotic resistance of pathogenic microorganism to existing antibiotics. Therefore the need to develop proficient, safe and inexpensive drugs from plant sources is of great importance.1 Antibiotic resistance has become a global concern. There has been an increasing incidence of multiple resistances in human pathogenic microorganisms in recent years, mostly due to haphazard use of commercial antimicrobial drugs commonly employed in the treatment of infectious diseases. This has forced scientists to search for new antimicrobial substances from various sources like the medicinal plants.