6%; p=0.036). Other vascular complications occurred in 9.1% of patients with early evero-limus vs 7.3% in the remaining cohort
(p=0.72). No wound healing complications were detected in the early everolimus group. There were similar rates of incisional hernia (p=0.31), infections (p=0.15), renal impairment (0.43), and histologi-cally proven acute cellular rejection (p=0.32) between groups. Hyperlipidemia rates were increased in the group early treated with everolimus (42.6% vs 3.6% at 3 years; p=0.018). There were neither differences in terms of graft loss (12.6% with early everolimus vs 21.3% with late or no everolimus at 3 years; p=0.25), nor regarding overall mortality (34.8% with early everolimus vs 29.1% with late or no everolimus at 3 years; p=0.88). CONCLUSION: Everolimus Selleck Sirolimus proved to be safe within the first month after LT. Randomized controlled trials implementing de novo everolimus after LT are warranted to confirm our findings. Disclosures: Enrique Fraga Rivas – Speaking and Teaching: Gilead, Janssen, MSD, BMS The following people have nothing to disclose: Indhira Perez Medrano, Manuel Rodríguez-Perálvarez, Marta Guerrero Misas, Mercedes ICG-001 research buy Muñoz Nuñez, Victor M. González Cosano, María Muñoz Garcia-Borruel, Antonio Poyato, Pilar Barrera Baena, Gustavo Ferrin, Guadalupe Costan Rodero, Juan Carlos Pozo Laderas, Marina Sanchez Frias, Ruben Ciria, Javier Briceho, Jose Luis Montero,
Manuel De la Mata Introduction: Biliary anastomotic stricture (AS) is a common complication after liver transplantation (LT). Therapeutic endo-scopic
retrograde cholangiopancreatography (ERCP) is the preferred management strategy but has potential complications and the pre-ERCP probability of finding AS should be high. In addition to laboratory studies, abdominal imaging is typically required to make a diagnosis of biliary AS. There is highly variable data on the effectiveness of different imaging modalities. Ultrasound (USS) can be performed at the bedside but is operator dependent and computerized tomography (CT) and Doxorubicin magnetic resonance imaging/cholangiopancreatography (MRI/ MRCP) are less operator dependent but more difficult to obtain quickly and require a degree of patient co-operation. Aim: To determine the effectiveness of different abdominal imaging studies in the diagnosis of biliary AS after LT. Methods: Patients who underwent ERCP demonstrating a biliary AS (defined by the cholangiographic appearance and improvement in laboratory parameters after stent therapy) at a single center were included. Imaging tests (USS, CT or MRI/MRCP) in the 30 days prior to the ERCP were noted. A positive imaging study was defined by the presence of biliary ductal dilation and/ or the presence of biliary AS. Results: A total of 50 patients were diagnosed with a biliary AS after LT at ERCP. The average age was 56.7 (+10.4) years and 80% were male.