, 2005). Even when these biologics are available, educational gaps or the absence of national recommendations may lead to their ineffective use (Folb and Cooke, 2007 and Wilde, 2007). Despite mTOR inhibitor its global public health burden, canine rabies could potentially be eliminated from the human population in the next decades, since all of the necessary tools have been developed, validated and used in some
form in specific parts of the world. Unfortunately, only rarely have all the tools been used in programs implemented in coordination at the same time and location. Achieving elimination will require governments, political leaders, local communities, international partners, subject-matter experts RAD001 in vitro and non-governmental organizations (NGOs) to embrace a shared vision, commit to a long-term strategy and work together to implement existing prophylactic and control measures (Hampson et al., 2011 and Lembo et al., 2011; Lembo and Partners for Rabies, 2012; Wilde et al., 2012). The prevention and control of emerging zoonoses requires cooperation among animal and human health sectors, ministries of education, local communities, international partners and NGOs (Arambulo, 2011, Batsukh et al., 2012 and Wright et al., 2008). Success in eliminating canine rabies will therefore
require a coordinated, integrated, interdisciplinary “One Health” approach (Briggs, 2012). Creating a sustainable and successful rabies prevention program requires strategic planning and the carefully orchestrated spatiotemporal distribution of interventions for both humans and animals (Rupprecht and Slate, 2012). Extensive experience in industrialized
countries and PIK3C2G ongoing programs in Latin America, Africa, and Asia have demonstrated that the elimination of canine rabies is an achievable goal (Kamoltham et al., 2003a, Lembo et al., 2010 and Schneider et al., 2011). All of these programs have had strong political support and have utilized a coordinated, evidence-based, community-oriented multidisciplinary approach. They have also avoided implementing one-sided strategies such as reliance on PEP without proper risk assessment, which is too costly and does not impact the source; indiscriminate dog culling without vaccination, which is unethical and ineffective; and canine vaccination without population management, which is unsustainable (Morters et al., 2013, Schneider et al., 2011 and WHO, 2010). In most countries where canine rabies is enzootic, control measures, supplies of vaccine and RIG, routine interventions, relevant recommendations and educational programs are either nonexistent or inoperative. The lack of effective educational outreach at the community level has led to gaps in knowledge as to the best way to avoid animal bites and administer first aid following bites or other potential rabies exposures.