Survival curves were constructed with the Kaplan–Meier method. In univariate, the log–rank test was used to evaluate the association between patient characteristics and overall survival. The incidence of harmful relapse was compared by means of the χ2-test, and multivariate logistic regression analysis was used to evaluate the association between patient characteristics and harmful relapse. JMP version 11.0 (SAS Institute, Cary, NC, USA) was used for the statistical analysis. Clinical and laboratory data were available for 195 patients (126 men and 69 women) who underwent LT in 36 of 38 institutions between November 1997 and December 2011.
The recipients’ ages ranged 25–69 years, with a median of 35 years. MELD score ranged 6–48, with a median of 20. Five patients had CTP scores
of A, 43 patients scores of B, 141 patients BGB324 manufacturer scores of C and six unknown scores. Six patients had hepatitis C infection, four were positive for hepatitis B DNA and 47 had hepatocellular carcinoma. GRWR ranged 0.44–2.4, with a median of 0.88. SLVR ranged 23.6–126.0%, with a median of 46.0%. The blood type combination was identical in 127, compatible in CH5424802 solubility dmso 49, incompatible in 17 and unknown in two patients. One hundred and eighty-seven patients underwent LDLT, five patients underwent DDLT and three patients had domino LT. The donors’ ages ranged 17–65 years, with a median of 52 years. Relationships of donors were sons or daughters in 86, spouses in 47, siblings in 38, parents in seven, nephews in four, cousins in one, an uncle in one, brothers-in-law in two, nephew-in-law Decitabine concentration in one, and non-relatives in seven consisting of six brain death donors and one domino donor. The length of the follow-up period ranged 3–4962 days, with a median of 1319 days. Among the 195 patients, 26 patients died before discharge after transplantation. Among the 169 patients who were discharged,
information about alcohol relapse was available in 140 patients. The relapse time was within 18 months after LT in 24 patients, after 18 months in two patients (in the 34th month and in the 37th month) and unknown in six patients (Fig. 1). Alcohol-related damage occurred in 18 (harmful relapse) of the 24 patients with recidivism within 18 months, in one of two patients with recidivism after 18 months and in two of six patients with unknown relapse time (Fig. 2). All 18 patients with harmful relapse had abnormal values of any hepatic chemistry, eight patients had abnormal pathological findings including steatosis in five and steatohepatitis in three, and one patient had psychiatric problem relating to alcoholism. To minimize the effects of the length of the period of drinking after transplantation on statistical analysis of survival, six patients with unknown relapse time and two patients with recidivism after 18 months were excluded from the following analysis.