; 1 g/d for 10 d), and oral tramadol (200 mg/d). Complete remission was observed 6 weeks later. Human envenomation caused by gastropods of the genus Conus is well known, although

only Trametinib mouse very few cases were reported in the literature.1,2 Divers and shell collectors are most frequently involved. Genus Conus (C.) includes more than 500 species. Cone shells are widely distributed in the Indo-Pacific. They may be found in shallow waters, under rocks, and along coral reefs.1 Cone species most frequently responsible for human envenomation are Conus geographus and Conus striatus. Other potentially dangerous species are Conus aulicus, Conus gloriamaris, Conus marmoreus, and C textile. Systemic symptoms and signs of cone envenomation include weakness, numbness, paraesthesia, ptosis, diplopia, aphonia, nausea, dysphagia, difficulty swallowing, acute anuria, dyspnoea, respiratory failure, absent reflexes, muscular paralysis, hypotension, and cardiac failure.1,2 Deaths occurred in India, Japan, Fiji Islands, Vanuatu Islands, New Caledonia, and Australia. It is estimated that

15% to 25% of all stings caused by C geographus are fatal.2 Death may be very rapid. Worst prognosis is in children. Skin lesions are often located on the hands and feet. Stinging or burning sensation or pain are initial symptoms.2 However, cone sting may be asymptomatic. Swelling, ischemia, cyanosis, CH5424802 price localized paraesthesia, and numbness are common.1,2 Pruritus is rare.1 Treatment of cone envenomation is symptomatic. Hot packs or immersion of the affected area in hot water can Flavopiridol (Alvocidib) be helpful. There

is no antivenom. Prevention is based on the use, by divers and shell collectors, of thick protective gloves. In this patient, as well as in another case we recently observed,3 the development of a cutaneous abscess was probably caused by the hot-humid climate, that facilitated multiple bacterial superinfections, and the application of several, unnecessary topical drugs. Skin and soft tissue bacterial infections are an emerging problem in travelers returning from tropical and subtropical countries. According to the results of a clinical and bacteriological study recently published,4 impetigo (35% of patients) and abscess (23%) are the two most frequent bacterial diseases of the skin. Lower limbs (75% of patients) are especially involved. Insect bites and stings are significantly associated with impetigo and ecthyma. Methicillin-susceptible S aureus (43% of patients), Group A Streptococcus (34%), and an association of both bacteria (23%) were isolated. Considering that methicillin-resistant S aureus is emerging worldwide, susceptibility tests should be always performed in travelers returning from tropical and subtropical countries with skin and soft tissue infections. The authors state they have no conflicts of interest to declare. “
“Two Japanese travelers from Bali were diagnosed with murine typhus in Japan during the same period.